Project Description

Renal Care-B®

Bicarbonate Haemodialysis Concentrate BP
Bicarbonate Component (Solution-B)


Bicarbonate is best given as acetate or lactate in order to avoid the release of Carbon Dioxide into the solution where Bicarbonate ion is the physiological buffer. Bicarbonate concentrate is used with acid concentrate.


Each 1 Liter concentrated solution contains

Sodium Chloride BP 30.50gm
Sodium Bicarbonate BP 66.00gm
Purified Water BP q.s. to 1 litre

Dilution Ratio

Renal Care-A & Renal Care-B to be used in the dilution ratio of:

Renal Care-A (Acidic) 1.00 vol
Renal Care-B (Bicarb) 1.83 vol
Purified water 34.00 vol

Clinical Pharmacology

Mechanism of Action:

Dialysis is a solution of electrolytes formulated in concentrations similar to those of extra cellular fluid or plasma. This solution allows to removal of water & metabolites and the replacement of electrolytes. In haemodialysis, the exchange of ions between the solution and the patient’s blood is made across a semi-permeable membrane, primarily by diffusion.


  • Acute renal failure.
  • Chronic renal failure
  • Overhydration
  • In Electrolyte and acid-base imbalance. Include hyperkalemia, metabolic acidosis, hypocalcaemia and hyperphosphatemia.
  • In treatment of poisoning
  • Treatment of renal failure occurring with P. Falciparum  infection ( malignant tertian malaria)


Not significant


  • Haemodialysis should be used with caution in patients with unstable cardiovascular disease or active bleeding.
  • Dialysis solutions should be warmed to body temperature with dry heat. Before and during treatment haemodynamic status, fluid balance, electrolyte and acid base balance should be closely monitored.
  • Do not use solution-A alone. Solution-A to be mixed with solution-B for haemodialysis.
  • Untreated tap/portable water is not suitable for the preparation of dialysates. Electrolyte concentration may need to be adjusted according to patient requirement.
  • Use only if solution is clear and must be diluted immediately before use with water of suitable quality.
  • This haemodialysis solution is not for i.v injection or infusion. It is used for haemodialysis purpose only.

Use in pregnancy and lactation

The hemodialysis may affect pregnancy, would be mothers are advised to consult their physician.

Drug interaction

In general, drugs of low molecular weight, high water solubility and low volume of distribution, low protein binding and high renal clearance are most extensively removed by dialysis. For example, Aminoglycosides are extensively removed by dialysis procedure and extra doses may be needed to replace losses.

Side effects

Side effects occurring during haemodialysis include nausea, vomiting, hypotension, muscle cramps and air embolus. Effects related to vascular access include infection, thrombosis and haemorrhage. Side effects are normally related to process haemodialysis. Side effects may also arise as a result of incorrect proportioning of dialysis solution.

Dosage and administration

Recommended Dose : As directed by the medical practioner
Dosage Schedule : 2-3 dialysis per week (as directed by the medical practioner)
Route of Administration : Not administered internally into patients. It is used for haemodialysis purpose only


Store between 150c-250c


Packed in 10 litres HDPE containers

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